We are pleased to announce the findings from Dr Robert Mathie’s latest clinical evidence update:

Total number of randomised controlled trials (RCTs):
2021: 255 RCTs of homeopathic treatments for 136 medical conditions

It is promising to see a slight increase in the volume of trials published per year, i.e. 14 RCTs in 2021, compared to 12 RCTs in 2020.

Double-blind placebo-controlled trials (DB-RCTs):
Considering only DB-RCTs in humans, published in peer reviewed journals (excluding prophylaxis and cross-over studies), the analysis found:

2020: 140 trials on 86 different medical conditions
2021: 148 trials on 88 different medical conditions

148 RCTs of homeopathy (end of 2021)


The 8 new DB-RCTs – 2 positive^1,2 0 negative and 6 inconclusive^3-8 trials – have resulted in a slight shift in the overall balance of evidence as follows:

Positive:         ↓ 1%
Negative:       ↓ 2%
Inconclusive: ↑ 2%

New DB-RCTs: 

1. Ghosh S, Ravindra RK, Modak A et al. Efficacy of individualized homeopathic medicines in primary dysmenorrhea: a double-blind, randomized, placebo-controlled, clinical trial. J Complement Integr Med 2021 Jun 3. doi: 10.1515/jcim-2020-0512. Online ahead of print.
2. Shahid S, Ghosh S, Chakraborty AS et al. Efficacy of Individualized Homeopathic Medicines in Plantar Fasciitis: Double-blind, Randomized, Placebo-Controlled Clinical Trial. Homeopathy 2021 Sep 07. DOI: 10.1055/s-0041-1731383. Online ahead of print.
3. Dey S, Hashmi S, Saha S et al. A Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Individualized Homeopathic Medicines for Cutaneous Warts. Homeopathy 2021 Aug;110(3):149-159
4. Dey S, Shaikh AR, Saha S et al. Efficacy of Individualized Homeopathic Medicines in the Treatment of Atopic Dermatitis in Adults: A Double-Blind, Randomized, Placebo-Controlled, Preliminary Trial. Complement Med Res 2021 Apr 15;1-10
5. Dolev T, Ben-David M, Shahadi I et al. Attention Dysregulation in Breast Cancer Patients Following a Complementary Alternative Treatment Routine: A Double-Blind Randomized Trial. Integrative Cancer Therapies 2021; 20: 1–10
6. Dutta S, Ganguly S, Mukherjee SK et al. Efficacy of individualized homeopathic medicines in intervening with the progression of pre-hypertension to hypertension: A double-blind, randomized, placebo-controlled trial. Explore (NY) 2021 Jun 5;S1550-8307(21)00098-7.
7. Parewa M, Burman AS, Brahma A et al. Individualized Homeopathic Medicines in the Treatment of Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled, Pilot Trial. Complement Med Res 2021; 28(5):407-418
8. Sadhukhan S, Singh S, Michael J et al. Individualized Homeopathic Medicines in Stage I Essential Hypertension: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial. J Altern Complement Med 2021 Jun; 27(6):515-521